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    Oral contraception: First

    Following the work of Chang and Djerassi and others, Gregory Pincus, the Director of the Worcester Foundation for experimental Biology had developed an effective contraceptive pill by 1957. The Pincus team, including Chang, began a systematic study, in the nineteen-fifties, of more than two hundred substances with varying effects on such things as ovulation, menstruation, and conception. One substance gestagen type, called "norethynodrel," formed the basis of the first large-scale trial of the contraceptive pill, a trial carried out in Puerto Rico in 1956. The gestagens, however, gave poor control over menstruation, a problem overcome by combining the gestagen with a synthetic oestrogen. It was a combined pill of this type (marketed commercially as Enovid) that proved so successful in the Puerto Rican trial. Now there are literally dozens of contraceptive pills available.


    From The Illustrated Book of Sexual Records.
    © 1974, 1982, 1997-2001 G.L. Simons

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